Author name: Richard Zhao

Clinician reviewing a brain scan for neuroscience care
患者科普-EN

Who May Be Considered for DBS in Addiction Care? A Guide to Candidate Assessment and Timing

Families often ask immediately whether their loved one can receive DBS. DBS is an emerging approach for severe, treatment-refractory addiction and requires careful clinical consideration; it is not appropriate for every person with addiction. Initial review may help clarify the situation, but the final decision depends on comprehensive specialist assessment.

Abstract molecular network visualisation for neuroscience
患者科普-EN

Targeting Persistent Craving: Understanding the Core Principles and Potential Advantages of BCI-Enabled DBS for Drug Addiction

Traditional approaches often help people through physical withdrawal and may include psychological support. Yet families often remain concerned about persistent craving and the learned patterns that can contribute to repeated return to use. This is one reason researchers are exploring brain-computer-interface and deep brain stimulation (DBS) approaches.

脑深部电刺激相关脑回路的教育示意图
患者科普-EN

Breaking Misconceptions: Drug Addiction Is Not Weak Willpower, but a Chronic Brain Disease Requiring Scientific Treatment

When people hear “drug addiction,” many immediately think the person lacks self-control or has poor character, and that determination alone should be enough to stop. Modern medicine has long reached a clear conclusion: drug addiction is not a matter of willpower or morality. It is a chronic, relapsing brain condition, medically described as drug dependence or substance-use disorder. Compulsive drug-seeking reflects a loss of control in the brain; it is not deliberate self-destruction. Both patients and families need to make this shift in understanding.

专业人士与研究资料

脑机接口 DBS 成瘾治疗的产业转化与行业应用进展

脑机接口 DBS 成瘾治疗的产业转化与行业应用进展 脑机接口 DBS 治疗药物成瘾是中国脑科学领域的原创性突破。本文梳理该技术从研发、临床试验到获批上市的全历程,总结其监管认证、学术交流与产业合作进展,呈现中国原创神经调控技术的产业转化路径。 一、企业技术发展历程 景昱医疗 2011 年创立于苏州,聚焦脑科学与植入式神经调控领域,从运动障碍疾病逐步拓展至精神疾病,全球首创脑机接口 DBS 治疗药物成瘾技术,是该领域的领导企业。 (一)产品研发与注册里程碑 技术首创期:全球首创脑机接口双靶点技术,启动单中心临床试验,验证技术可行性; 循证积累期:完成全球首个样本量最大的多中心随机对照注册临床试验,积累高级别循证证据; 获批上市期:2025 年 12 月 15

专业人士与研究资料

DBS 治疗难治性阿片类成瘾的长期临床疗效与安全性证据

DBS 治疗难治性阿片类成瘾的长期临床疗效与安全性证据 高复吸率是药物成瘾治疗的核心难题。本文基于单中心临床试验与第三方长期随访数据,系统评价脑机接口双靶点 DBS 治疗难治性阿片类成瘾的戒断率、渴求改善效应与神经安全性,为临床决策提供循证依据。 一、单中心探索性临床试验(2014-2018) (一)研究设计 该研究为开放性单中心试点研究,入组 8 例难治性海洛因依赖患者,采用 NAc+ALIC 双靶点 DBS 植入治疗,开机后随访 24 个月。 判定标准:连续 2 周尿检阳性,或自我报告每周≥2 次药物接触判定为复吸;失访按阳性计。

专业人士与研究资料

脑机接口 DBS 双靶点治疗药物成瘾的作用机制与程控原理

脑机接口 DBS 双靶点治疗药物成瘾的作用机制与程控原理 脑机接口双靶点 DBS 是难治性药物成瘾的突破性技术。本文解析伏隔核(NAc)- 内囊前肢(ALIC)双靶点联合刺激的神经机制,阐述 DBS 系统的程控参数体系与可控、可逆技术特性,为神经外科医师、程控工程师提供技术参考。 一、DBS 治疗成瘾的核心逻辑 脑深部电刺激通过植入式电极向脑内特定靶点释放慢性高频电刺激,干预成瘾相关异常神经环路,调控环路功能状态,削弱患者对药物的心理依赖,最终降低戒断后复吸风险。 与传统射频毁损术不同,DBS 不造成永久性脑组织损伤,治疗效应可通过电参数精细化调节,是精神疾病外科治疗的主流微创方案。 二、NAc+ALIC 双靶点协同作用机制 脑机接口双靶点技术,同时覆盖奖赏环路与冲动控制环路,实现多维度协同干预。 (一)伏隔核(NAc)靶点:纠正奖赏环路异常 伏隔核是大脑奖赏环路的中枢节点。长期用药会导致伏隔核功能紊乱,奖赏阈值升高,患者陷入 “用药

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